Author

Ogechukwu Mbegbu

Translational Genomics Research Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Genomics· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 3 Assay:Hi-C· 3 Organism:human· 3 Research Focus:chromatin & epigenetic regulation· 1 Assay:fluorescence / live-cell microscopy· 1 Research Focus:gene regulatory network inference· 1 Assay:long-read sequencing· 1 Research Focus:spatial domain detection· 1

Frequent Co-Authors

Floris P BartheliD· 3 shared Noelle H. Fukushima· 3 shared T. Rhyker Ranallo-BenavideziD· 3 shared Tianpeng ZhangiD· 2 shared Yue HaoiD· 2 shared Ava Bryan· 1 shared Benedict PateniD· 1 shared Danyael Murphy· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersGenomics

Floris P BarthelORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Telomere Dysfunction in Human Astrocytes Drives Acrocentric Chromosome Instability and Nucleolar Reorganization

Ogechukwu Mbegbu, Yi-An Chen, Yue Hao, Noelle H. Fukushima, T. Rhyker Ranallo-Benavidez, Ava Bryan, Szehoi Chan, Nikki N. Messick, Maria Kyriakidou, Tianpeng Zhang, Pippa F. Cosper, Floris P Barthel

This study shows that telomere dysfunction in human astrocytes leads to acrocentric chromosome instability and nucleolar reorganization through a combination of cytogenetic, imaging, and chromatin-contact analyses.

bioRxiv · May 21, 2026 · PreprintCancer Biology

Mapping the Telomeric 3D Interactome with Telomere-C Reveals Repetitive Element Hubs Associated with Telomere Maintenance

Yi‐An Chen, Ogechukwu Mbegbu, Noelle H. Fukushima, T. Rhyker Ranallo-Benavidez, Tianpeng Zhang, Floris P Barthel

The paper introduces Telomere-C, a method to map telomeric 3D interactions, revealing ultra-long-range contacts and repetitive element hubs linked to telomere maintenance.

bioRxiv · Oct 9, 2025 · PreprintGenomics

Diploid genome assembly of human fibroblast cell lines enables clone specific variant calling, improved read mapping and accurate phasing

T. Rhyker Ranallo-Benavidez, Yue Hao, Emilia Volpe, Maryam Jehangir, Noelle H. Fukushima, Ogechukwu Mbegbu, Rebecca A. Reiman, Jessica Molnar, Danyael Murphy, Dorothy Marie Paredes, Shukmei Wong, Kara Karaniuk, Stephanie Buchholtz, Jonathan J. Keats, Mitchell J. Machiela, , Floris P Barthel

The paper presents diploid genome assemblies for two human fibroblast cell lines, enabling clone-specific variant calling, improved read mapping, and accurate phasing.

bioRxiv · Apr 15, 2025 · PreprintGenomics