Telomere Dysfunction in Human Astrocytes Drives Acrocentric Chromosome Instability and Nucleolar Reorganization
Ogechukwu Mbegbu, Yi-An Chen, Yue Hao, Noelle H. Fukushima, T. Rhyker Ranallo-Benavidez, Ava Bryan, Szehoi Chan, Nikki N. Messick, Maria Kyriakidou, Tianpeng Zhang, Pippa F. Cosper, Floris P Barthel
This study shows that telomere dysfunction in human astrocytes leads to acrocentric chromosome instability and nucleolar reorganization through a combination of cytogenetic, imaging, and chromatin-contact analyses.
bioRxiv · May 21, 2026 · PreprintCancer Biology