Author

Yi-An Chen

Translational Genomics Research InstitutePrimary ORCID profile (0000-0003-4936-8060 · 1 paper)Unclaimed ORCID profile · follow to get notified of new preprints

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Same name, identified by ORCID

Yi-An CheniD1 paper · National Institute of Biomedical Innovation, Health and Nutrition

Biology Disciplines

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Cancer Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:drug response / drug discovery· 1 Assay:fluorescence / live-cell microscopy· 1 Assay:Hi-C· 1 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Alfur Fu-Hsin Hung· 1 shared Ava Bryan· 1 shared Birthe B. Kragelund· 1 shared Chi-Fon Chang· 1 shared Chih-Neng Hsu· 1 shared Chu-Hsuan Chiu· 1 shared Chun-Mei Hu· 1 shared Daniel Laio· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperPhysiology

Alfur Fu-Hsin Hung

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Telomere Dysfunction in Human Astrocytes Drives Acrocentric Chromosome Instability and Nucleolar Reorganization

Ogechukwu Mbegbu, Yi-An Chen, Yue Hao, Noelle H. Fukushima, T. Rhyker Ranallo-Benavidez, Ava Bryan, Szehoi Chan, Nikki N. Messick, Maria Kyriakidou, Tianpeng Zhang, Pippa F. Cosper, Floris P Barthel

This study shows that telomere dysfunction in human astrocytes leads to acrocentric chromosome instability and nucleolar reorganization through a combination of cytogenetic, imaging, and chromatin-contact analyses.

bioRxiv · May 21, 2026 · PreprintCancer Biology

Identification of PTGR2 inhibitors as a new therapy for diabetes and obesity

Yi-Cheng Chang, Meng-Lun Hsieh, Hsiao-Lin Lee, Siow-Wey Hee, Chi-Fon Chang, Hsin-Yung Yen, Yi-An Chen, Yet-Ran Chen, Ya-Wen Chou, Fu-An Li, Yi-Yu Ke, Shih-Yi Chen, Ming-Shiu Hung, Alfur Fu-Hsin Hung, Jing-Yong Huang, , Lee-Ming Chuang

The paper identifies PTGR2 inhibitors as a new therapy for diabetes and obesity by improving glucose homeostasis and preventing diet-induced obesity without side effects.

bioRxiv · Dec 17, 2024 · PreprintPhysiology