Tianpeng Zhang

Telomere Dysfunction in Human Astrocytes Drives Acrocentric Chromosome Instability and Nucleolar Reorganization

This study shows that telomere dysfunction in human astrocytes leads to acrocentric chromosome instability and nucleolar reorganization through a combination of cytogenetic, imaging, and chromatin-contact analyses.

Mapping the Telomeric 3D Interactome with Telomere-C Reveals Repetitive Element Hubs Associated with Telomere Maintenance

The paper introduces Telomere-C, a method to map telomeric 3D interactions, revealing ultra-long-range contacts and repetitive element hubs linked to telomere maintenance.

Fork Reversal Safeguards Epigenetic Inheritance during DNA Replication Under Stress

This study shows that replication fork reversal is essential for maintaining epigenetic inheritance under replication stress by preventing nucleosome loss and ensuring histone transfer.

CHAMP1 complex directs heterochromatin assembly and promotes homology-directed DNA repair

This study identifies the CHAMP1 complex's role in heterochromatin assembly and its enhancement of homology-directed DNA repair in specific genomic regions.