Macrolide resistance through uL4 and uL22 ribosomal mutations in Pseudomonas aeruginosa
Lise Goltermann, Pablo Laborda, Oihane Irazoqui, Ivan Pogrebnyakov, Maria Pals Bendixen, Søren Molin, Helle Krogh Johansen, Ruggero La Rosa
This study shows that macrolides are effective against Pseudomonas aeruginosa in airway infections but lead to resistance via uL4 and uL22 ribosomal mutations, requiring higher antibiotic concentrations and reducing bacterial fitness.
Nature Communications · Oct 16, 2024Peer-reviewedMicrobiology