Ruggero La Rosa

Human airway model reveals host-pathogen co-infection dynamics of Staphylococcus aureus and Pseudomonas aeruginosa

The paper uses a human airway model to study co-infection dynamics between Staphylococcus aureus and Pseudomonas aeruginosa, revealing strain-specific traits and secretion systems that influence microbial competition.

Carbapenem-resistance oprD mutations reshape Pseudomonas aeruginosa host-pathogen interactions during infection

This study shows that OprD mutations in Pseudomonas aeruginosa enhance bacterial attachment and translocation across airway epithelial barriers, altering infection dynamics beyond antibiotic resistance.

Immune protection and disease tolerance in Pseudomonas aeruginosa infections by pyruvate cross-feeding

The paper identifies pyruvate cross-feeding as a mechanism enabling Pseudomonas aeruginosa persistence in chronic infections by modulating host immune responses and oxidative stress.

Infection dynamics and virulence potential of clinical Pseudomonas aeruginosa isolates in human airway epithelial models

The paper investigates infection dynamics and virulence of Pseudomonas aeruginosa in human airway epithelial models, identifying four infection clusters based on strain-specific virulence and host response.

Macrolide resistance through uL4 and uL22 ribosomal mutations in Pseudomonas aeruginosa

This study shows that macrolides are effective against Pseudomonas aeruginosa in airway infections but lead to resistance via uL4 and uL22 ribosomal mutations, requiring higher antibiotic concentrations and reducing bacterial fitness.