Maria Pals Bendixen

The paper investigates infection dynamics and virulence of Pseudomonas aeruginosa in human airway epithelial models, identifying four infection clusters based on strain-specific virulence and host response.

This study shows that macrolides are effective against Pseudomonas aeruginosa in airway infections but lead to resistance via uL4 and uL22 ribosomal mutations, requiring higher antibiotic concentrations and reducing bacterial fitness.