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This study shows that dequalinium chloride induces transient collateral sensitivity in Pseudomonas aeruginosa by competing for OprM, a shared component of efflux pumps.

This study shows that OprD mutations in Pseudomonas aeruginosa enhance bacterial attachment and translocation across airway epithelial barriers, altering infection dynamics beyond antibiotic resistance.

This paper develops a dual-cell air-liquid interface model to study epithelial-immune interactions during airway infection, finding that macrophages modulate inflammation and bacterial distribution.

The paper identifies pyruvate cross-feeding as a mechanism enabling Pseudomonas aeruginosa persistence in chronic infections by modulating host immune responses and oxidative stress.

This study shows that macrolides are effective against Pseudomonas aeruginosa in airway infections but lead to resistance via uL4 and uL22 ribosomal mutations, requiring higher antibiotic concentrations and reducing bacterial fitness.