Neus Prats

This paper describes the development of HYL001, a TGFβ inhibitor that effectively combats microsatellite stable CRC metastasis in mice when combined with immune checkpoint therapy.

This study uses single-cell RNA sequencing to map the in vivo reprogramming trajectory from acinar cells to pluripotency in the pancreas and identifies conserved intermediate markers across tissues.

This study shows that p62 is involved in Lafora body formation and that its absence reduces glycogen aggregation in muscle and heart but worsens brain pathology in a mouse model of Lafora disease.

This study shows that Slc7a7 deficiency in mice causes erythropoiesis failure and iron overload, with erythropoietin supplementation as a potential therapy for LPI.

The paper shows that GEMC1 and CCNO are essential for efferent duct development and male fertility in mice, with defects in multiciliated cell formation leading to infertility.