Human Cytomegalovirus UL78 is a Nuclear-Localized GPCR Necessary for Efficient Reactivation from Latent Infection in CD34+ Hematopoietic Progenitor Cells
Samuel Medica, Nicole L. Diggins, Michael C. Denton, Rebekah Turner, Lydia J. Pung, Adam T. Mayo, Olivia Kramer Hansen, Jennifer Mitchell, Luke Slind, Linh K. Nguyen, Teresa Beechwood, Gauthami Sulgey, Craig N. Kreklywich, Daniel Malouli, METTE MARIE ROSENKILDE, , Meaghan H. Hancock
This study identifies UL78 as a nuclear-localized GPCR essential for HCMV reactivation from latency in CD34+ HPCs, showing its Gi coupling and interactome involvement in nuclear processes.
Journal of Virology · Oct 8, 2025Peer-reviewedMicrobiology