Author

Michael C. Denton

Oregon Health & Science University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Organism:human· 2 Assay:proteomics· 2 Organism:rat· 2 Research Focus:cell-cell communication· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Daniel N. StreblowiD· 4 shared Craig N. Kreklywich· 3 shared Lydia J. Pung· 3 shared Samuel MedicaiD· 3 shared Aaron M. Barber-Axthelm· 2 shared Caralyn S. LabriolaiD· 2 shared Christopher J. Parkins· 2 shared Gavin Zilverberg· 2 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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4 shared papersMicrobiology

Daniel N. StreblowORCID

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Author profile →

4 papers

Recent·Most cited

The human cytomegalovirus chemokine binding protein UL22A is necessary for efficient reactivation from latency in CD34+ hematopoietic progenitor cells.

Rebekah Turner, Nicole L. Diggins, Luke Slind, Jennifer Mitchell, Andrew H. Pham, Christopher J. Parkins, Wilma D. Perez, Samuel Medica, Michael C. Denton, Takeshi F. Andoh, Gabriela M. Webb, Daniel Andrade-Vera, Daniel N. Streblow, Patrizia Caposio, Meaghan H. Hancock

This paper shows that HCMV's UL22A protein is essential for reactivation from latency in CD34+ hematopoietic progenitor cells, with tyrosine residues critical for this process, but RANTES neutralization does not fully restore reactivation.

Journal of Virology · Jul 27, 2026Peer-reviewedMicrobiology

Infection Of Rhesus Macaques With Onyong-nyong Virus UVIR-O804 Recapitulates Key Aspects of Human Clinical Disease

Hannah K. Jaeger, Michael C. Denton, Takeshi F. Andoh, Craig N. Kreklywich, Lina Gao, Lydia J. Pung, Zachary J. Streblow, Ann McMonigal, Karina Ray, Brayden Graves, Magdalene M. Streblow, Aaron M. Barber-Axthelm, Gavin Zilverberg, Margaret Terry, Suzanne S. Fei, , Daniel N. Streblow

This study infects rhesus macaques with a recent ONNV clinical isolate, demonstrating viremia, immune activation, and clinical disease features similar to human infection.

bioRxiv · Nov 20, 2025 · PreprintMicrobiology

A Zika Virus-Like Particle Vaccine Mitigates Early Pregnancy Loss In Rhesus Macaques

Hannah K. Jaeger, Jessica R. Smith, Caralyn S. Labriola, Lydia J. Pung, Olivia L. Hagen, Michael C. Denton, Rahul J. D'Mello, Christopher J. Parkins, Whitney C. Weber, Samuel Medica, Craig N. Kreklywich, Victor R. DeFilippis, Stephen Bondoc, Kathleen Busman‐Sahay, Jenna N. Castro, , Alec J. Hirsch

This study evaluates a Zika virus-like particle (VLP) vaccine in rhesus macaques, showing it reduces early pregnancy loss caused by a highly pathogenic ZIKV strain.

bioRxiv · Oct 16, 2025 · PreprintMicrobiology

Human Cytomegalovirus UL78 is a Nuclear-Localized GPCR Necessary for Efficient Reactivation from Latent Infection in CD34+ Hematopoietic Progenitor Cells

Samuel Medica, Nicole L. Diggins, Michael C. Denton, Rebekah Turner, Lydia J. Pung, Adam T. Mayo, Olivia Kramer Hansen, Jennifer Mitchell, Luke Slind, Linh K. Nguyen, Teresa Beechwood, Gauthami Sulgey, Craig N. Kreklywich, Daniel Malouli, METTE MARIE ROSENKILDE, , Meaghan H. Hancock

This study identifies UL78 as a nuclear-localized GPCR essential for HCMV reactivation from latency in CD34+ HPCs, showing its Gi coupling and interactome involvement in nuclear processes.

Journal of Virology · Oct 8, 2025Peer-reviewedMicrobiology