Dexamethasone impairs glycolysis but improves mycobacterial killing in primary human macrophages
Lorraine Thong, Olivia Sandby Thomas, Oisin Ó Gallchobhair, Emily Duffin, Anjali S Yennemadi, Gina R. Leisching, Dearbhla M Murphy, Parthiban Nadarajan, Fiona O’ Connell, Mary P O’Sullivan, Sharee A. Basdeo, Donal J Cox, Joseph Keane
This study shows dexamethasone reduces glycolysis in human macrophages but enhances mycobacterial killing, suggesting a potential therapeutic benefit in tuberculosis.
bioRxiv · Jun 27, 2025 · PreprintImmunology