Cell polarity proteins promote macropinocytosis in response to metabolic stress
G. Lambies, S.-W. Lee, K. Duong-Polk, P. Aza-Blanc, S. Maganti, D. W. Dawson, C. Commisso
This study identifies aPKC enzymes as regulators of macropinocytosis in PDAC cells under glutamine stress, showing their role in cell survival and tumor growth.
bioRxiv · Jan 16, 2024Cancer Biology