Author

S. Maganti

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:drug response / drug discovery· 2 Approach:statistical model· 2 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

C. Commisso· 2 shared A. Chakraborty· 1 shared A. M. Lowy· 1 shared C. Fraser· 1 shared C. M. Galapate· 1 shared D. A. Scott· 1 shared D. W. Dawson· 1 shared E. Esparza· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersCancer Biology

C. Commisso

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Cell polarity proteins promote macropinocytosis in response to metabolic stress

G. Lambies, S.-W. Lee, K. Duong-Polk, P. Aza-Blanc, S. Maganti, D. W. Dawson, C. Commisso

This study identifies aPKC enzymes as regulators of macropinocytosis in PDAC cells under glutamine stress, showing their role in cell survival and tumor growth.

bioRxiv · Jan 16, 2024Cancer Biology

Glutamine mimicry suppresses tumor progression through asparagine metabolism in pancreatic ductal adenocarcinoma

M. V. Recouvreux, C. M. Galapate, S. Grenier, E. Esparza, Y. Zhang, S. Maganti, R. Naeem, D. A. Scott, A. M. Lowy, H. Tiriac, C. Commisso

This study shows that DON inhibits PDAC growth by targeting asparagine metabolism, and combining DON with ASNase reduces metastasis.

Nature Cancer · Oct 9, 2023Peer-reviewedCancer Biology

A Mesenchymal Tumor Cell State Confers Increased Dependency on the BCL-XL Anti-apoptotic Protein in Kidney Cancer

T. M. Grubb, S. Maganti, J. M. Krill-Burger, C. Fraser, L. Stransky, T. Radivoyevitch, K. Sarosiek, F. Vazquez, W. G. Kaelin, A. Chakraborty

The paper identifies a mesenchymal tumor cell state that increases dependency on BCL-XL in kidney cancer, showing anti-tumor efficacy of a BCL-XL inhibitor.

bioRxiv · Jan 29, 2022 · PreprintCancer Biology