P. Brun

Comparative CNS Pharmacology of the Brutons Tyrosine Kinase (BTK) Inhibitor Tolebrutinib Versus Other BTK Inhibitor Candidates for Treating Multiple Sclerosis.

This paper compares the CNS pharmacology of three BTK inhibitors in non-human primates, finding that tolebrutinib achieves higher CSF exposure than the others.

Evaluation of Autophagy in conjunctival fibroblasts

The paper evaluates autophagy in conjunctival fibroblasts using immunocytochemistry, immunoblotting, and qPCR to understand its role in vernal keratoconjunctivitis.

Rank-based deep learning from citizen-science data to model plant communities

The paper uses deep learning to model plant species distributions and community composition from citizen-science data, showing improved accuracy over traditional methods.

Strategies for sampling pseudo-absences for species distribution models in complex mountainous terrain

This study evaluates pseudo-absence strategies for species distribution models in complex mountainous terrain, finding that generic and species-specific approaches can produce robust predictions, with environmental stratification improving performance in biased datasets.

A novel effective live-attenuated human metapneumovirus vaccine candidate produced in the serum-free suspension DuckCelt-T17 cell platform

This study evaluates the use of DuckCelt-T17 avian cells for producing a live-attenuated HMPV vaccine candidate, showing its efficiency and scalability.

Transcriptional profiling of immune and inflammatory responses in the context of SARS-CoV-2 fungal superinfection in a human airway epithelial model

The paper compares the transcriptional responses of SARS-CoV-2 and Aspergillus superinfection in human airway epithelial models, identifying unique immune and inflammatory signatures.

Characterization and treatment of SARS-CoV-2 in nasal and bronchial human airway epithelia

The paper characterizes SARS-CoV-2 infection in nasal and bronchial airway epithelial models and evaluates the antiviral efficacy of remdesivir and its combination with diltiazem.