Author

J.-F. Eleouet

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Immunology· 3 Biochemistry· 1 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:human· 7 Research Focus:host-pathogen & immune response· 4 Research Focus:cell type annotation· 3 Research Focus:drug response / drug discovery· 3 Assay:cryo-EM· 2 Approach:deep learning· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

M. Galloux· 6 shared M.-A. Rameix-Welti· 3 shared B. Correia· 2 shared C. Yang· 2 shared C.-A. Richard· 2 shared D. Descamps· 2 shared F. Sesterhenn· 2 shared H. Decool· 2 shared

Activity by Year

2018-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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6 shared papersMicrobiology

M. Galloux

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Structure of the N-RNA/P interface reveals mode of L/P attachment to the nucleocapsid of human metapneumovirus

J. D. Whitehead, H. Decool, C. Leyrat, L. Carrique, J. Fix, J.-F. Eleouet, M. Galloux, M. Renner

The paper determines the structure of the N-RNA/P triple complex in human metapneumovirus, revealing how the polymerase attaches to the RNA template and providing a basis for therapeutic design.

bioRxiv · Jun 10, 2023 · PreprintMicrobiology

Specific targeting and clustering of Phosphatidylserine lipids by RSV M protein is critical for virus particle production

J. M. Swain, M. Bierre, L. Veyrie, C.-A. Richard, J.-F. Eleouet, D. MURIAUX, M. Bajorek

This study shows RSV M protein binds phosphatidylserine lipids, promoting viral assembly, and identifies lipid interactions critical for virus production.

bioRxiv · Mar 13, 2023 · PreprintBiochemistry

Structural landscape of the Respiratory Syncytial Virus nucleocapsids

L. Gonnin, A. Desfosses, M. Bacia-Verloop, D. Chevret, M. Galloux, J.-F. Eleouet, I. Gutsche

This paper presents cryo-EM structures of RSV nucleocapsids, revealing their polymorphism and unique helical symmetry due to C-terminal N interactions.

bioRxiv · Feb 14, 2023Microbiology

A novel effective live-attenuated human metapneumovirus vaccine candidate produced in the serum-free suspension DuckCelt-T17 cell platform

C. Chupin, A. Pizzorno, A. Traversier, P. Brun, D. Ogonczyk-makowska, B. Padey, C. Milesi, V. Duliere, E. Laurent, T. Julien, M. Galloux, B. Lina, J.-F. Eleouet, K. Moreau, M.-E. Hamelin, , M. Rosa-Calatrava

This study evaluates the use of DuckCelt-T17 avian cells for producing a live-attenuated HMPV vaccine candidate, showing its efficiency and scalability.

bioRxiv · Aug 30, 2021 · PreprintImmunology

Characterization of the interaction domains between the phosphoprotein and the nucleocapsid of human Metapneumovirus

H. Decool, B. Bardiaux, L. C. Ruano, O. Sperandio, J. Fix, I. Gutsche, C.-A. Richard, M. Bajorek, J.-F. Eleouet, M. Galloux

This paper identifies the specific domains of the HMPV phosphoprotein (P) and nucleocapsid (NNuc) that mediate their interaction, showing the C-terminal 6 residues of P and the N-terminal domain of N are critical.

bioRxiv · Jun 2, 2021Microbiology

Pulmonary mesenchymal stem cells are engaged in distinct steps of host response to respiratory syncytial virus infection

M. Brugger, T. Demoulins, G. T. Barut, B. Zumkehr, B. Oliveira Esteves, K. Mehinagic, Q. Haas, A. Schogler, M.-A. Rameix-Welti, J.-F. Eleouet, U. Moehrlen, T. Marti, R. Schmid, A. Summerfield, H. Posthaus, , M. P. Alves

The paper investigates the role of lung-resident mesenchymal stem cells in the host response to RSV infection, showing their activation and involvement in antiviral, inflammatory, and repair processes.

bioRxiv · May 12, 2021Microbiology

Interferon-induced Protein-44 and Interferon-induced Protein 44-like restrict replication of Respiratory Syncytial Virus

D. C. Busse, D. Habgood-Coote, S. Clare, C. Brandt, I. Bassano, M. Kafarou, J. Herberg, M. Levin, J.-F. Eleouet, P. Kellam, J. S. Tregoning

This study shows that IFI44 and IFI44L restrict RSV replication and are anti-viral and anti-proliferative, with IFI44L serving as a diagnostic marker for viral infection.

bioRxiv · Feb 24, 2020Immunology

De novo protein design enables precise induction of functional antibodies in vivo

F. Sesterhenn, C. Yang, J. Cramer, J. Bonet, X. Wen, L. Abriata, I. Kucharska, C.-I. Chiang, Y. Wang, G. Castoro, S. Vollers, M. Galloux, R. Charles-Adrien, E. Dheilly, S. Rosset, , B. Correia

This paper introduces a de novo protein design algorithm called TopoBuilder that generates immunogens inducing precise antibody responses against respiratory syncytial virus in mice and non-human primates.

bioRxiv · Feb 14, 2020 · PreprintBioengineering

Boosting subdominant neutralizing antibody responses with a computationally designed epitope-focused immunogen

F. Sesterhenn, M. Galloux, S. S. Vollers, L. Csepregi, C. Yang, D. Descamps, J. Bonet, S. Friedensohn, P. Gainza, P. Corthesy, M. Chen, S. Rosset, M.-A. Rameix-Welti, J.-F. Eleouet, S. T. Reddy, , B. Correia

This study demonstrates that a computationally designed epitope-focused immunogen enhances subdominant neutralizing antibody responses against RSV.

bioRxiv · Nov 22, 2018Immunology