Author

P. C. Ruben

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Assay:electrophysiology· 3 Approach:experimental assay· 3 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:synaptic & neural circuits· 1

Frequent Co-Authors

M.-R. Ghovanloo· 2 shared A. D. Williams· 1 shared C. H. Peters· 1 shared C. J. Cohen· 1 shared F. Scott· 1 shared J. Johnson· 1 shared J. Mezeyova· 1 shared J. R. Empfield· 1 shared

Activity by Year

2017-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersPharmacology & Toxicology

M.-R. Ghovanloo

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Author profile →

3 papers

Recent·Most cited

Molecular pharmacology of selective NaV1.6 and dual NaV1.6 and NaV1.2 channel inhibitors that suppress excitatory neuronal activity ex vivo

S. J. Goodchild, N. G. Shuart, A. D. Williams, W. Ye, R. R. Parrish, M. Soriano, S. Thouta, J. Mezeyova, M. Waldbrook, R. A. Dean, T. Focken, M.-R. Ghovanloo, P. C. Ruben, F. Scott, C. J. Cohen, , J. Johnson

This paper introduces selective NaV1.6 and dual NaV1.6/NaV1.2 inhibitors that suppress excitatory neuronal activity ex vivo, showing selectivity over NaV1.1 and efficacy in seizure models.

bioRxiv · Aug 3, 2023Pharmacology & Toxicology

Protein kinases mediate anti-inflammatory effects of cannabidiol and estradiol against high glucose in cardiac sodium channels

M. A. Foouda, P. C. Ruben

This study shows that inflammation and PK-A/PK-C activation mediate high glucose-induced Nav1.5 gating defects, which are reversed by CBD and E2, suggesting a potential therapeutic role for CBD in diabetic arrhythmias.

bioRxiv · Nov 23, 2020Pharmacology & Toxicology

A Mixed Periodic Paralysis & Myotonia Mutant, P1158S, Imparts pH Sensitivity in Skeletal Muscle Voltage-gated Sodium Channels

M.-R. Ghovanloo, M. Abdelsayed, C. H. Peters, P. C. Ruben

This paper shows that the P1158S mutation in Nav1.4 makes skeletal muscle sodium channels sensitive to pH changes, leading to myotonia and periodic paralysis under acidic conditions.

bioRxiv · Jul 17, 2017Biophysics