Author

P. Caposio

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Research Focus:host-pathogen & immune response· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 1 Organism:mouse· 1

Frequent Co-Authors

C. J. Parkins· 2 shared D. K. Collins-McMillen· 2 shared F. Goodrum· 2 shared J. Mitchell· 2 shared M. H. Hancock· 2 shared A. H. Pham· 1 shared C. Parkins· 1 shared D. De Oliveira Pessoa· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersMicrobiology

C. J. Parkins

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4 papers

Recent·Most cited

Viral microRNA regulation of Akt is necessary for reactivation of Human Cytomegalovirus from latency in CD34+ hematopoietic progenitor cells and humanized mice

N. L. Diggins, A. H. Pham, J. Mitchell, C. J. Parkins, L. Slind, R. Turner, P. Caposio, J. A. Nelson, M. H. Hancock

This study shows that HCMV miRNAs downregulate Akt to promote reactivation from latency in CD34+ cells and humanized mice.

bioRxiv · May 24, 2024 · PreprintMicrobiology

Viral and host network analysis of the human cytomegalovirus transcriptome in latency.

D. K. Collins-McMillen, D. De Oliveira Pessoa, K. Zarrella, C. J. Parkins, M. Daily, N. K. Moorman, J. P. Kamil, P. Caposio, M. Padi, F. Goodrum

The paper analyzes the transcriptional network of HCMV in latency by comparing gene expression with and without UL135 and UL138, revealing their roles in viral gene regulation and hematopoietic differentiation.

bioRxiv · May 21, 2024Microbiology

UL135 and UL136 Epistasis Controls Reactivation of Human Cytomegalovirus

M. A. Moy, D. K. Collins-McMillen, L. Crawford, C. Parkins, S. Zeltzer, K. Caviness, P. Caposio, F. Goodrum

This study shows that stabilizing UL136p33 compensates for the loss of UL135 in HCMV reactivation from latency in hematopoietic cells.

bioRxiv · Jan 24, 2023 · PreprintMicrobiology

Human cytomegalovirus UL7, miR-US5-1 and miR-UL112-3p inactivation of FOXO3a protects CD34+ hematopoietic progenitor cells from apoptosis

M. H. Hancock, L. B. Crawford, W. Perez, H. M. Struthers, J. Mitchell, P. Caposio

This study identifies HCMV proteins and miRNAs that inhibit FOXO3a to prevent apoptosis in CD34+ hematopoietic progenitor cells, aiding viral latency.

bioRxiv · Sep 28, 2020Microbiology