The BCKDK inhibitor BT2 is a chemical uncoupler that lowers mitochondrial ROS production and de novo lipogenesis
A. Acevedo, A. E. Jones, B. T. Danna, R. Turner, K. P. Montales, C. Beninca, K. Reue, O. S. Shirihai, L. Stiles, M. Wallace, Y. Wang, A. M. Bertholet, A. S. Divakaruni
The paper shows BT2 acts as a mitochondrial uncoupler, reducing ROS and lipogenesis, which may explain its therapeutic benefits in metabolic diseases.
bioRxiv · Aug 15, 2023 · PreprintBiochemistry