Antidepressant-like effect of losartan involves TRKB transactivation from angiotensin receptor type 2 (AGTR2) and recruitment of FYN
C. R. Alves Faria Diniz, P. Casarotto, S. M. Fred, C. Biojone, E. Castren, S. R. L. Joca
This study shows losartan has antidepressant-like effects via AGTR2-mediated TRKB transactivation and FYN recruitment in brain regions.
bioRxiv · Mar 13, 2018Pharmacology & Toxicology