Author

S. M. Fred

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

E. Castren· 2 shared C. Biojone· 1 shared C. Brunello· 1 shared C. R. Alves Faria Diniz· 1 shared H. Goos· 1 shared I. Cardon· 1 shared L. Laukkanen· 1 shared L. Vesa· 1 shared

Activity by Year

2018-2019 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersPharmacology & Toxicology

E. Castren

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2 papers

Recent·Most cited

Pharmacologically diverse antidepressant drugs disrupt the interaction of BDNF receptor TRKB and the endocytic adaptor AP-2

S. M. Fred, L. Laukkanen, C. Brunello, L. Vesa, H. Goos, I. Cardon, R. Moliner, T. Maritzen, M. Varjosalo, P. C. Casarotto, E. Castren

This study shows that multiple antidepressants disrupt the TRKB:AP2M interaction, affecting TRKB surface expression and BDNF signaling.

bioRxiv · Sep 30, 2019Pharmacology & Toxicology

Antidepressant-like effect of losartan involves TRKB transactivation from angiotensin receptor type 2 (AGTR2) and recruitment of FYN

C. R. Alves Faria Diniz, P. Casarotto, S. M. Fred, C. Biojone, E. Castren, S. R. L. Joca

This study shows losartan has antidepressant-like effects via AGTR2-mediated TRKB transactivation and FYN recruitment in brain regions.

bioRxiv · Mar 13, 2018Pharmacology & Toxicology