Regulation of DNA damage response by trimeric G-protein Signaling
A. A. Abd El-Hafeez, N. Sun, A. Chakraborty, J. Ear, S. Roy, P. Chamarthi, N. Rajapakse, S. Das, K. E. Luker, T. K. Hazra, G. D. Luker, P. Ghosh
This paper shows that GIV/Girdin modulates DNA damage response by suppressing HR and promoting NHEJ through BRCA1 sequestration and Akt pathway activation.
bioRxiv · Jul 21, 2021 · PreprintCancer Biology