Author

N. Rajapakse

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cell Biology· 3 Biochemistry· 1 Cancer Biology· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 6 Research Focus:cell signaling & trafficking· 5 Research Focus:cell type annotation· 3 Organism:human· 3 Assay:proteomics· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:development & morphogenesis· 2 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

P. Ghosh· 5 shared D. Sahoo· 3 shared J. Ear· 3 shared S. Roy· 3 shared C. Rohena· 2 shared I. Kufareva· 2 shared J. Choi· 2 shared M. Ghassemian· 2 shared

Activity by Year

2019-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

5 shared papersCell Biology

P. Ghosh

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Men in menopause? Experimental verification of the mate choice theory with Drosophila melanogaster shows both sexes can undergo menopause

D. Purohith, M. Chaudhary, A. Gomes, N. Rajapakse, A. Das, N. Dhanvanthry, M. Brown, M. Mukherjee, R. S. Singh

This study tests the mate choice theory of menopause using Drosophila melanogaster, showing that both sexes can experience fertility decline in old age due to asymmetric mating.

bioRxiv · Apr 18, 2022 · PreprintEvolutionary Biology

Regulation of DNA damage response by trimeric G-protein Signaling

A. A. Abd El-Hafeez, N. Sun, A. Chakraborty, J. Ear, S. Roy, P. Chamarthi, N. Rajapakse, S. Das, K. E. Luker, T. K. Hazra, G. D. Luker, P. Ghosh

This paper shows that GIV/Girdin modulates DNA damage response by suppressing HR and promoting NHEJ through BRCA1 sequestration and Akt pathway activation.

bioRxiv · Jul 21, 2021 · PreprintCancer Biology

Evolution of Modularity, Interactome and Functions of GIV/Girdin (CCDC88A) from Invertebrates to Vertebrates

J. Ear, A. Ali Abd El-Hafeez, S. Roy, T. Ngo, N. Rajapakse, J. Choi, S. Khandelwal, M. Ghassemian, L. McCaffrey, I. Kufareva, D. Sahoo, P. Ghosh

The paper examines the evolutionary changes in GIV/Girdin's modularity, interactome, and functions across invertebrates and vertebrates, revealing distinct roles in cancer as tumor suppressor or oncogene.

bioRxiv · Sep 28, 2020 · PreprintBiochemistry

GIV-Kindlin interaction is required for Kindlin-Mediated Integrin Recognition and Activation

C. Rohena, N. Kalogriopoulos, N. Rajapakse, S. Roy, I. Lopez-Sanchez, J. Ablack, D. Sahoo, P. Ghosh

This paper shows that GIV binds Kindlin-2 to enhance integrin activation, promoting cell adhesion and invasion, and links this interaction to metastasis in tumor transcriptomics.

bioRxiv · Dec 10, 2019Cell Biology

GIV/Girdin and Exo70 Constitute the Core of the Mammalian Polarized Exocytic Machinery

C. Rohena, N. Rajapakse, I.-C. Lo, P. Novick, D. Sahoo, P. Ghosh

This paper identifies GIV/Girdin as the mammalian homolog of yeast Bem1p, showing it binds Exo70 and is essential for polarized exocytosis, matrix metalloprotease delivery, and cell invasion.

bioRxiv · Dec 9, 2019Cell Biology

Tyrosine-based Signals Regulate the assembly of Daple-PARD3 Complex at Cell-cell Junctions during Polarized Planar Cell Migration

J. Ear, A. Saklecha, N. Rajapakse, J. Choi, M. Ghassemian, I. Kufareva, P. Ghosh

The paper shows that tyrosine phosphorylation regulates Daple-PARD3 complex assembly at cell-cell junctions, influencing planar cell polarity during migration.

bioRxiv · Dec 4, 2019 · PreprintCell Biology