G. D. Luker

Predicting efficacy of immunotherapy in mice with triple negative breast cancer using a cholesterol PET radiotracer

The paper uses a cholesterol PET radiotracer to predict immunotherapy response in TNBC mouse models by measuring T cell cholesterol uptake.

A Multiomic Analysis Reveals How Breast Cancers Disseminated to the Bone Marrow Acquire Aggressive Phenotypes through Tumor-Stroma Tunnels

This study identifies GIV as a key protein transferred from mesenchymal stromal cells to ER+ breast cancer cells via tunnelling nanotubes, driving aggressive tumor phenotypes.

Growth Signaling Autonomy in Circulating Tumor Cells Aids Metastatic Seeding

This study defines the transcriptome, proteome, and phenome of growth signaling autonomy in breast cancer cells and shows its role in metastatic progression and drug resistance.

Molecular insights into intrinsic transducer-coupling bias in the CXCR4-CXCR7 system

This study characterizes the biased agonism of CXCR4 and CXCR7, revealing differences in G-protein coupling, β-arrestin recruitment, and ERK1/2 activation.

Cell-to-cell variability of dynamic CXCL12-CXCR4 signaling and morphological processes in chemotaxis

The paper analyzes single-cell chemotaxis in breast cancer cells using CXCL12-CXCR4 signaling, identifying dynamic signaling oscillations and morphological changes as key factors in successful migration.

Regulation of DNA damage response by trimeric G-protein Signaling

This paper shows that GIV/Girdin modulates DNA damage response by suppressing HR and promoting NHEJ through BRCA1 sequestration and Akt pathway activation.

Fiber density and matrix stiffness modulate distinct cell migration modes in a 3D stroma mimetic composite hydrogel

This study investigates how matrix fiber density and stiffness influence different migration modes in MCF10A cells and their apoptotic resistance.