Mechanical dysfunction induced by a hypertrophic cardiomyopathy mutation is the primary driver of cellular adaptation
S. R. Clippinger, P. E. Cloonan, W. Wang, L. Greenberg, W. T. Stump, P. Angsutararux, J. M. Nerbonne, M. J. Greenberg
This study shows that a HCM mutation causes mechanical dysfunction, which drives cellular adaptation through altered force generation and signaling pathways.
bioRxiv · May 4, 2020Biophysics