M. Ernst

Mutant TP53 switches therapeutic vulnerability during gastric cancer progression within Interleukin-6 family cytokines

This study identifies IL6/STAT3 signaling as a therapeutic target for TP53-mutant gastric cancer by showing its role in metastatic progression driven by mutant Trp53.

Dimerization mechanism of an inverted-topology ion channel in membranes

This study investigates the dimerization mechanism of the inverted-topology fluoride channel Fluc, showing that membrane forces drive assembly while Na+ binding activates the channel.

Trachymyrmex septentrionalis ants promote fungus garden hygiene using Trichoderma-derived metabolite cues

This paper identifies Trichoderma as a pathogen of fungus gardens and shows that peptaibols, its metabolites, trigger ant weeding behavior to maintain garden hygiene.

A single-molecule method for measuring fluorophore labeling yields for the study of membrane protein oligomerization in membranes

This paper introduces a method to estimate fluorophore labeling yields for membrane proteins using photobleaching analysis of a dimeric control, improving quantification of oligomerization without prior labeling measurement.

Neural resources shift under Methylphenidate: a computational approach to examine anxiety-cognition interplay

This study examines how methylphenidate affects neural resource allocation during cognitive tasks under anxiety using computational and topological methods.

The kinase activity of the cancer stem cell marker DCLK1 drives gastric cancer progression by reprogramming the stromal tumor landscape

This study identifies DCLK1 kinase activity as a driver of gastric cancer progression by reprogramming the tumor stroma and promoting invasiveness and metastasis.

The minor spliceosome offers a therapeutically viable target for the treatment of a broad spectrum of cancers

This study shows that targeting the minor spliceosome, specifically Rnpc3, reduces tumor burden in multiple cancer models and is associated with poor patient survival in cancer transcriptomes.

Biomolecular solid-state NMR spectroscopy at highest field: the gain in resolution at 1200 MHz

This paper demonstrates improved resolution in biomolecular solid-state NMR spectroscopy at 1200 MHz, showing higher peak resolution in 13C spectra and aliphatic side-chain resonances in 1H spectra compared to 850 MHz.

EHF is essential for epidermal and colonic epithelial homeostasis and suppresses Apc-initiated colonic tumorigenesis

This study shows that EHF is essential for epidermal and colonic epithelial homeostasis and acts as a tumor suppressor in colorectal cancer.

Dual MAPK and HDAC inhibition rewires the apoptotic rheostat to trigger colorectal cancer cell death

This study shows that combining MEK/ERK and HDAC inhibition synergistically induces apoptosis in colorectal cancer cells and organoids, and can be tailored to specific MAPK genotypes.

MolNetEnhancer: enhanced molecular networks by integrating metabolome mining and annotation tools

MolNetEnhancer integrates metabolomics tools to improve chemical annotation and structural insight from mass spectrometry data.

Disrupted mechanobiology links the molecular and cellular phenotypes in familial dilated cardiomyopathy

This study investigates how a mutation in troponin-T affects cellular contractility and mechanosensing in familial dilated cardiomyopathy.

Comprehensive mass spectrometry-guided plant specialized metabolite phenotyping reveals metabolic diversity in the cosmopolitan plant family Rhamnaceae

The paper introduces a workflow for large-scale metabolite annotation in Rhamnaceae plants, revealing metabolic diversity and identifying clade-specific biosynthetic pathways.

Identification of the bacterial biosynthetic gene clusters of the oral microbiome illuminates the unexplored social language of bacteria during health and disease

This study identifies 4,915 bacterial biosynthetic gene clusters in the oral microbiome and finds differential representation of BGCs in health versus disease states like dental caries and periodontitis.

Untargeted Mass Spectrometry-Based Metabolomics Tracks Molecular Changes in Raw and Processed Foods and Beverages

This paper uses untargeted mass spectrometry to analyze chemical changes in foods during preparation and storage, finding that some processes alter molecular composition while others primarily involve extraction.