Author

W. T. Stump

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 5 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 5 Approach:statistical model· 3 Research Focus:cell signaling & trafficking· 2 Approach:deep learning· 2 Approach:experimental assay· 2 Assay:proteomics· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1

Frequent Co-Authors

M. J. Greenberg· 6 shared L. Greenberg· 4 shared S. R. Clippinger· 3 shared A. L. Bredemeyer· 2 shared P. E. Cloonan· 2 shared T. Blackwell· 2 shared A. E. Greenberg· 1 shared A. L. Bailey· 1 shared

Activity by Year

2019-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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6 shared papersBiophysics

M. J. Greenberg

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Harnessing molecular mechanism for precision medicine in dilated cardiomyopathy caused by a mutation in troponin T

L. Greenberg, W. T. Stump, Z. J. Lin, A. L. Bredemeyer, T. Blackwell, X. Hao, A. E. Greenberg, B. Garcia, K. Lavine, M. J. Greenberg

This study connects genotype, phenotype, and drug response in dilated cardiomyopathy using molecular mechanism-based computational and experimental approaches for a troponin T mutation.

bioRxiv · Apr 5, 2024 · PreprintBiophysics

Single Molecule Mechanics and Kinetics of Cardiac Myosin Interacting with Regulated Thin Filaments

S. R. Clippinger Schulte, B. Scott, S. K. Barrick, W. T. Stump, T. Blackwell, M. J. Greenberg

This study investigates how thin filament regulatory proteins affect the mechanics and kinetics of cardiac myosin using single-molecule techniques, finding no significant impact at physiological ATP concentrations but some effects at low ATP.

bioRxiv · Jan 9, 2023Biophysics

SARS-CoV-2 Infects Human Engineered Heart Tissues and Models COVID-19 Myocarditis

A. L. Bailey, O. Dmytrenko, L. Greenberg, A. L. Bredemeyer, P. Ma, J. Liu, V. Penna, L. Lai, E. S. Winkler, S. Sviben, E. Brooks, A. P. Nair, K. A. Heck, A. S. Rali, L. Simpson, , K. J. Lavine

This study shows SARS-CoV-2 infects human engineered heart tissues, causing myocarditis-like features, and identifies ACE2 and proteases as entry factors.

bioRxiv · Nov 4, 2020Immunology

Computational Tool for Ensemble Averaging of Single-Molecule Data

T. J. Blackwell, W. T. Stump, S. R. Clippinger, M. J. Greenberg

The paper introduces a computational tool, SPASM, for ensemble averaging of single-molecule data to improve the accuracy of measuring mechanochemical coupling in molecular motors.

bioRxiv · Aug 10, 2020Biophysics

Mechanical dysfunction induced by a hypertrophic cardiomyopathy mutation is the primary driver of cellular adaptation

S. R. Clippinger, P. E. Cloonan, W. Wang, L. Greenberg, W. T. Stump, P. Angsutararux, J. M. Nerbonne, M. J. Greenberg

This study shows that a HCM mutation causes mechanical dysfunction, which drives cellular adaptation through altered force generation and signaling pathways.

bioRxiv · May 4, 2020Biophysics

Disrupted mechanobiology links the molecular and cellular phenotypes in familial dilated cardiomyopathy

S. R. Clippinger, P. E. Cloonan, L. Greenberg, M. Ernst, W. T. Stump, M. J. Greenberg

This study investigates how a mutation in troponin-T affects cellular contractility and mechanosensing in familial dilated cardiomyopathy.

bioRxiv · Feb 21, 2019Biophysics