Gain-of-function genetic screen of the kinome reveals BRSK2 as an inhibitor of the NRF2 transcription factor
T. Y. Tamir, B. M. Bowman, M. J. Agajanian, D. Goldfarb, T. P. Schrank, T. Stohrer, A. E. Hale, P. F. Siesser, S. J. Weir, R. M. Murphy, K. M. LaPak, B. E. Weissman, N. J. Moorman, M. B. Major
The paper identifies BRSK2 as a negative regulator of NRF2 by inhibiting protein synthesis through mTOR downregulation, suggesting it as a potential therapeutic target for NRF2-related diseases.
bioRxiv · Nov 5, 2019Cell Biology