Author

T. Y. Tamir

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Approach:genetic perturbation / CRISPR· 1 Assay:proteomics· 1

Frequent Co-Authors

M. B. Major· 3 shared A. D. Axtman· 1 shared A. E. Hale· 1 shared B. E. Weissman· 1 shared B. M. Bowman· 1 shared B. M. Fujita· 1 shared C. Wells· 1 shared D. Goldfarb· 1 shared

Activity by Year

2019-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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3 shared papersCell Biology

M. B. Major

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Author profile →

3 papers

Recent·Most cited

Pharmacology & ToxicologybioRxivJun 15, 2020

PKIS Deep Dive Yields a Chemical Starting Point for Dark Kinases and a Cell Active BRSK2 Inhibitor

T. Y. Tamir, D. H. Drewry, C. Wells…·A. D. Axtman

The paper investigates GW296115, a PKIS compound, showing it inhibits six dark kinases, including BRSK2, with IC50 values under 100nM and demonstrates cell activity.

DOI 10.1038/s41598-020-72869-9

experimental assaydrug response / drug discovery

𝕏 PostBluesky

Cell BiologybioRxivNov 5, 2019

Gain-of-function genetic screen of the kinome reveals BRSK2 as an inhibitor of the NRF2 transcription factor

T. Y. Tamir, B. M. Bowman, M. J. Agajanian…·M. B. Major

The paper identifies BRSK2 as a negative regulator of NRF2 by inhibiting protein synthesis through mTOR downregulation, suggesting it as a potential therapeutic target for NRF2-related diseases.

DOI 10.1242/jcs.241356

humanbulk RNA-seq

𝕏 PostBluesky

Cell BiologybioRxivAug 12, 2019

The MyMOMA domain of MYO19 encodes for distinct Miro-dependent and Miro-independent mechanisms of interaction with mitochondrial membranes

J. L. Bocanegra, B. M. Fujita, N. R. Melton…·O. A. Quintero

This study identifies distinct Miro-dependent and Miro-independent mechanisms by which MYO19 interacts with mitochondrial membranes through its MyMOMA domain.

DOI 10.1002/cm.21560

humanproteomics

𝕏 PostBluesky