Author

K. Kihn

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:host-pathogen & immune response· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Approach:statistical model· 1

Frequent Co-Authors

D. Deredge· 2 shared A. Boldrini· 1 shared A. Gershenson· 1 shared C. N. Smith· 1 shared D. A. Lawrence· 1 shared D. Liberg· 1 shared E. H. Klontz· 1 shared E. J. Sundberg· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersImmunology

D. Deredge

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Long range allostery mediates the regulation of plasminogen activator inhibitor 1 by vitronectin

K. Kihn, E. Marchiori, G. Spagnolli, A. Boldrini, L. Terruzzi, D. A. Lawrence, A. Gershenson, P. Faccioli, P. L. Wintrode

This study uses simulations to show vitronectin regulates PAI-1 latency transition by reducing RCL and gate mobility through long-range allostery, revealing a cryptic drug binding site.

bioRxiv · Jul 19, 2022 · PreprintBiophysics

Molecular basis of selective cytokine signaling inhibition by antibodies targeting a shared receptor

J. K. Fields, K. Kihn, G. S. Birkedal, E. H. Klontz, K. Sjöström, S. Günther, R. Beadenkopf, G. Forsberg, D. Liberg, G. A. Snyder, D. Deredge, E. J. Sundberg

This study shows that antibodies targeting IL-1RAcP can selectively block signaling by different IL-1 family cytokines based on distinct epitopes they engage.

Frontiers in Immunology · Dec 24, 2021Peer-reviewedImmunology

Development and validation of nanobodies specifically targeting the oncogenic Phosphatase of Regenerating Liver-3 (PRL-3)

C. N. Smith, K. Kihn, Z. A. Williamson, Y. Chernyavskyay, K. M. Chow, L. B. Hersh, K. V. Korotkov, D. Deredge, J. S. Blackburn

This paper develops and validates nanobodies that specifically target PRL-3, showing high specificity over PRL-1 and PRL-2 and providing tools to study PRL-3 function in cancer.

bioRxiv · Oct 2, 2020 · PreprintBiochemistry