Cancer BiologybioRxivPreprint
A novel small molecule that induces cytotoxicity in lung cancer cells inhibits disulfide reductases GSR and TXNRD1
F. D. Johnson, J. Ferrarone, A. Liu…·W. W. Lockwood
The paper identifies LCS3, a compound that induces oxidative stress in lung cancer cells by inhibiting disulfide reductases GSR and TXNRD1, and shows its synergistic effect with glutathione and thioredoxin pathway inhibition.
DOI 10.1101/2021.06.28.450088