Author

G. C. Forcina

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Biochemistry· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:drug response / drug discovery· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Research Focus:host-pathogen & immune response· 1 Assay:imaging· 1 Approach:microscopy & imaging analysis· 1

Frequent Co-Authors

S. J. Dixon· 3 shared C. R. Bertozzi· 2 shared A. Kuo· 1 shared A. Liu· 1 shared A. Nagelberg· 1 shared B. M. George· 1 shared C. Brandstadter· 1 shared C. L. Miller· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersCancer Biology

S. J. Dixon

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Design of a mucin-selective protease for targeted degradation of cancer-associated mucins

K. Pedram, D. J. Shon, G. S. Tender, N. R. Mantuano, J. J. Northey, K. J. Metcalf, S. P. Wisnovsky, N. M. Riley, G. C. Forcina, S. A. Malaker, A. Kuo, B. M. George, C. L. Miller, K. M. Casey, J. G. Vilches-Moure, , C. R. Bertozzi

This paper designs a mucin-selective protease conjugated to a nanobody to degrade cancer-associated mucins, showing reduced tumor growth in mouse models.

bioRxiv · May 20, 2022Biochemistry

Ferroptosis Regulation by the NGLY1/NFE2L1 Pathway

G. C. Forcina, L. Pope, M. Murray, W. Dong, M. Abu-Remaileh, C. R. Bertozzi, S. J. Dixon

This study identifies the NGLY1/NFE2L1 pathway as a regulator of ferroptosis, showing that NGLY1-mediated deglycosylation of NFE2L1 is necessary for its anti-ferroptotic function through GPX4 expression.

bioRxiv · Oct 12, 2021Cell Biology

A novel small molecule that induces cytotoxicity in lung cancer cells inhibits disulfide reductases GSR and TXNRD1

F. D. Johnson, J. Ferrarone, A. Liu, C. Brandstadter, R. Munuganti, D. Fansworth, D. Lu, J. Luu, T. Sihota, S. Jansen, A. Nagelberg, R. Shi, G. C. Forcina, X. Zhang, G. S. W. Cheng, , W. W. Lockwood

The paper identifies LCS3, a compound that induces oxidative stress in lung cancer cells by inhibiting disulfide reductases GSR and TXNRD1, and shows its synergistic effect with glutathione and thioredoxin pathway inhibition.

bioRxiv · Jun 28, 2021 · PreprintCancer Biology

Large-Scale Analysis of Cell Death Phenotypic Heterogeneity

Z. Inde, G. C. Forcina, K. Denton, S. J. Dixon

This study quantifies and compares fractional killing of cancer cells across multiple lethal agents and cell lines using high-throughput time-lapse imaging, revealing MCL1's role in MAPK inhibitor-induced cell death.

bioRxiv · Feb 28, 2020 · PreprintCancer Biology