Author

F. D. Johnson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:drug response / drug discovery· 1 Assay:proteomics· 1

Frequent Co-Authors

D. Lu· 2 shared G. de Rappard-Yuswack· 2 shared R. Shi· 2 shared R. Somwar· 2 shared A. Liu· 1 shared A. M. Unni· 1 shared A. Nagelberg· 1 shared C. Brandstadter· 1 shared

Activity by Year

2021-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersCancer Biology

D. Lu

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2 papers

Recent·Most cited

MEK inhibitor resistance in lung cancer cells associated with addiction to sustained ERK suppression

D. A. Farnsworth, Y. Inoue, F. D. Johnson, G. de Rappard-Yuswack, D. Lu, R. Shi, R. Somwar, M. Ladanyi, A. M. Unni, W. Lockwood

The paper identifies drug addiction to MEK inhibitors in KRAS-mutant lung cancer cells, showing that resistance is linked to ERK suppression and KRAS amplification, suggesting therapeutic strategies involving drug holidays.

bioRxiv · Apr 29, 2022 · PreprintCancer Biology

A novel small molecule that induces cytotoxicity in lung cancer cells inhibits disulfide reductases GSR and TXNRD1

F. D. Johnson, J. Ferrarone, A. Liu, C. Brandstadter, R. Munuganti, D. Fansworth, D. Lu, J. Luu, T. Sihota, S. Jansen, A. Nagelberg, R. Shi, G. C. Forcina, X. Zhang, G. S. W. Cheng, , W. W. Lockwood

The paper identifies LCS3, a compound that induces oxidative stress in lung cancer cells by inhibiting disulfide reductases GSR and TXNRD1, and shows its synergistic effect with glutathione and thioredoxin pathway inhibition.

bioRxiv · Jun 28, 2021 · PreprintCancer Biology