Author

W. W. Lockwood

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Assay:proteomics· 1 Assay:whole-exome sequencing· 1

Frequent Co-Authors

H. Varmus· 2 shared A. Liu· 1 shared A. M. Unni· 1 shared A. Nagelberg· 1 shared C. Brandstadter· 1 shared D. Fansworth· 1 shared D. Lu· 1 shared F. D. Johnson· 1 shared

Activity by Year

2016-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersCancer Biology

H. Varmus

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2 papers

Recent·Most cited

A novel small molecule that induces cytotoxicity in lung cancer cells inhibits disulfide reductases GSR and TXNRD1

F. D. Johnson, J. Ferrarone, A. Liu, C. Brandstadter, R. Munuganti, D. Fansworth, D. Lu, J. Luu, T. Sihota, S. Jansen, A. Nagelberg, R. Shi, G. C. Forcina, X. Zhang, G. S. W. Cheng, , W. W. Lockwood

The paper identifies LCS3, a compound that induces oxidative stress in lung cancer cells by inhibiting disulfide reductases GSR and TXNRD1, and shows its synergistic effect with glutathione and thioredoxin pathway inhibition.

bioRxiv · Jun 28, 2021 · PreprintCancer Biology

How Cancer Genomics Drives Cancer Biology: Does Synthetic Lethality Explain Mutually Exclusive Oncogenic Mutations?

H. Varmus, A. M. Unni, W. W. Lockwood

The paper investigates mutual exclusivity of KRAS and EGFR mutations in lung adenocarcinomas, suggesting synthetic lethality explains their absence in co-occurring tumors.

bioRxiv · Dec 18, 2016Cancer Biology