P. H. V. Saavedra

This paper identifies WNK1 as essential for macrophage lineage fidelity, showing its role in preventing myeloid progenitors from differentiating into neutrophils.

This study identifies butyrate, a microbiota-derived metabolite, as a regulator of peripheral efferocytosis, showing its ability to restore impaired phagocytic clearance in antibiotic-treated mice.

This study identifies the NACHT domain of wildtype NLRP3 as the target of MCC950/CRID3, showing it inhibits inflammasome activity but not CAPS-associated mutants.

This study shows that secreted molecules from Cryptococcus neoformans inhibit inflammasome-dependent macrophage responses, reducing antifungal activity and enhancing fungal survival.