Author

A. H. Tavares

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Biochemistry· 1 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:host-pathogen & immune response· 5 Approach:experimental assay· 4 Organism:human· 4 Assay:proteomics· 3 Assay:imaging· 1 Approach:microscopy & imaging analysis· 1 Organism:mouse· 1

Frequent Co-Authors

M. Saeed· 4 shared D. Kenney· 3 shared F. Douam· 3 shared N. Khan· 3 shared A. Emili· 2 shared D. N. Kotton· 2 shared D.-Y. Chen· 2 shared H. L. Conway· 2 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersMicrobiology

M. Saeed

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Role of spike in the pathogenic and antigenic behavior of SARS-CoV-2 BA.1Omicron

D.-Y. Chen, D. Kenney, C.-V. Chin, A. H. Tavares, N. Khan, H. L. Conway, G. Liu, M. C. Choudhary, H. P. Gertje, A. K. O'Connell, D. N. Kotton, A. Herrmann, A. Ensser, J. H. Connor, M. Bosmann, , M. Saeed

This study compares the pathogenicity and immune evasion of an Omicron S-bearing virus with natural Omicron, showing vaccine escape via S mutations but severe disease due to factors outside S.

bioRxiv · Oct 13, 2022 · PreprintMicrobiology

High resolution photocatalytic mapping of SARS-CoV-2 Spike protein-host cell membrane interactions

S. Datta, A. H. Tavares, T. Reyes-Robles, K. A. Ryu, N. Khan, T. J. Bechtel, J. M. Bertoch, C. H. White, D. J. Hazuda, K. A. Vora, E. C. Hett, O. O. Fadeyi, R. C. Oslund, M. Saeed, A. Emili

This study identifies additional host proteins involved in SARS-CoV-2 entry using a novel photocatalytic mapping platform called ViraMap.

bioRxiv · Sep 2, 2022 · PreprintBiochemistry

SARS-CoV-2 Requires Cholesterol for Viral Entry and Pathological Syncytia Formation

D. W. Sanders, C. C. Jumper, P. J. Ackerman, D. Bracha, A. Donlic, H. Kim, D. Kenney, I. Castello-Serrano, S. Suzuki, T. Tamura, A. H. Tavares, M. Saeed, A. S. Holehouse, A. Ploss, I. Levental, , C. P. Brangwynne

This study identifies cholesterol's essential role in SARS-CoV-2 membrane fusion and syncytia formation, suggesting statins may benefit COVID-19 patients.

bioRxiv · Dec 14, 2020Cell Biology

SARS-CoV-2 desensitizes host cells to interferon through inhibition of the JAK-STAT pathway

D.-Y. Chen, N. Khan, B. J. Close, R. K. Goel, B. Blum, A. H. Tavares, D. Kenney, H. L. Conway, J. K. Ewoldt, S. Kapell, V. C. Chitalia, N. A. Crossland, C. S. Chen, D. N. Kotton, S. C. Baker, , M. Saeed

This study identifies SARS-CoV-2 inhibition of the JAK-STAT pathway as a mechanism to suppress interferon signaling across diverse cell types.

bioRxiv · Oct 27, 2020 · PreprintMicrobiology

Cryptococcus neoformans secretes small molecules that inhibit IL-1β inflammasome-dependent secretion

P. H. Bürgel, C. L. Marina, P. H. V. Saavedra, P. Albuquerque, P. H. Holanda, R. d. A. Castro, H. Heyman, C. Coelho, R. J. B. Cordero, A. Casadevall, J. Nosanchuk, E. Nakayasu, R. C. May, A. H. Tavares, A. Bocca

This study shows that secreted molecules from Cryptococcus neoformans inhibit inflammasome-dependent macrophage responses, reducing antifungal activity and enhancing fungal survival.

bioRxiv · Feb 19, 2019Immunology