Author

J. S. A. Perry

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Cell Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell signaling & trafficking· 4 Organism:mouse· 4 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:development & morphogenesis· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:metabolism & bioenergetics· 1

Frequent Co-Authors

C. D. Lucas· 3 shared W. S. Rojas· 3 shared Z. Wang· 3 shared A. H. Settle· 2 shared A. Trzeciak· 2 shared B. Y. Winer· 2 shared M. Huse· 2 shared P. H. V. Saavedra· 2 shared

Activity by Year

2022-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersImmunology

C. D. Lucas

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

β2 integrins impose a mechanical checkpoint on macrophage phagocytosis

A. H. Settle, B. Y. Winer, M. M. de Jesus, L. Seeman, Z. Wang, E. Chan, Y. Romin, L. Zhuoning, M. M. Miele, R. C. Hendrickson, D. Vorselen, J. S. A. Perry, M. Huse

This study shows that β2 integrins regulate macrophage phagocytosis based on cargo rigidity, acting as a mechanical checkpoint to control engulfment strategies.

bioRxiv · Feb 20, 2024Cell Biology

Plasma membrane abundance dictates phagocytic capacity and functional crosstalk in myeloid cells

B. Y. Winer, A. H. Settle, A. M. Yakimov, C. Jeronimo, T. Lazarovt, M. Tipping, M. Saoi, A. Sawh, A.-L. L. Sepp, M. Galiano, J. S. A. Perry, Y. Y. Wong, F. Geissmann, J. Cross, T. Zhou, , M. Huse

This study shows that plasma membrane abundance regulates phagocytic capacity and post-phagocytic migration in myeloid cells, with G{beta}4 deficiency leading to increased phagocytosis and altered trafficking.

bioRxiv · Sep 12, 2023 · PreprintCell Biology

WNK1 enforces macrophage lineage fidelity

A. J. Trzeciak, W. S. Rojas, Z.-L. Liu, A. S. Krebs, Z. Wang, P. H. V. Saavedra, I. C. Miranda, A. Lipshutz, J. Xie, C.-L. Huang, M. Overholtzer, M. S. Glickman, C. N. Parkhurst, T. Vierbuchen, C. D. Lucas, J. S. A. Perry

This paper identifies WNK1 as essential for macrophage lineage fidelity, showing its role in preventing myeloid progenitors from differentiating into neutrophils.

bioRxiv · Apr 26, 2023 · PreprintImmunology

A microbiota-derived metabolite instructs peripheral efferocytosis

P. H. V. Saavedra, A. Trzeciak, Z. Wang, W. S. Rojas, G. Zago, M. D. Docampo, J. G. Verter, M. R. M. van den Brink, C. D. Lucas, C. J. Anderson, A. Y. Rudensky, J. S. A. Perry

This study identifies butyrate, a microbiota-derived metabolite, as a regulator of peripheral efferocytosis, showing its ability to restore impaired phagocytic clearance in antibiotic-treated mice.

bioRxiv · Aug 17, 2022Immunology

Novel adaptation supports enhanced macrophage efferocytosis in limited-oxygen environments

Y.-T. Wang, A. Trzeciak, W. S. Rojas, P. Saavedra, Y.-T. Chen, R. Chirayil, J. I. Etchegaray, C. D. Lucas, D. J. Puleston, K. R. Keshari, J. S. A. Perry

This study identifies two macrophage states induced by chronic hypoxia that enhance efferocytosis through metabolic and transcriptional adaptations.

bioRxiv · Aug 4, 2022Immunology