Author

P. Sacha

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Bioengineering· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:imaging· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

J. Konvalinka· 3 shared L. Kostka· 2 shared V. Subrt· 2 shared A. Fossoul· 1 shared A. Simkova· 1 shared B. L. Lee· 1 shared C. E. Stivala· 1 shared D. Demon· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersBiochemistry

J. Konvalinka

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Author profile →

3 papers

Recent·Most cited

Sensitive quantification of fibroblast activation protein and high-throughput screening for inhibition by FDA-approved compounds

K. Cermakova, A. Simkova, F. Wichterle, R. Krystufek, J. Stanurova, P. Busek, J. Konvalinka, P. Sacha

The paper presents a qPCR-based method for high-throughput screening of FDA-approved compounds as FAP inhibitors and demonstrates its application in quantifying FAP in human plasma.

bioRxiv · Jun 25, 2024Biochemistry

Polymer-tethered quenched fluorescent probes for enhanced imaging of tumor associated proteases

M. Hadzima, F. F. Faucher, K. Blazkova, J. J. Yim, M. Guerra, S. Chen, E. C. Woods, K. W. Park, P. Sacha, V. Subrt, L. Kostka, T. Etrych, J. Konvalinka, M. Bogyo

This paper develops polymer-tethered fluorescent probes for tumor-associated protease imaging, showing improved signal and tumor-to-background ratios compared to small molecule probes.

bioRxiv · May 6, 2024Bioengineering

MCC950/CRID3 potently targets the NACHT domain of wildtype NLRP3 but not disease-associated mutants for inflammasome inhibition

L. Vande Walle, I. B. Stowe, P. Sacha, B. L. Lee, D. Demon, A. Fossoul, F. Van Hauwermeiren, P. H. V. Saavedra, P. Simon, V. Subrt, L. Kostka, C. E. Stivala, V. C. Pham, S. T. Staben, S. Yamazoe, , M. Lamkanfi

This study identifies the NACHT domain of wildtype NLRP3 as the target of MCC950/CRID3, showing it inhibits inflammasome activity but not CAPS-associated mutants.

bioRxiv · May 11, 2019Immunology