Author

P. J. Aruscavage

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:protein folding & dynamics· 2 Approach:biophysical modeling· 1 Organism:C. elegans· 1 Assay:protein sequence· 1

Frequent Co-Authors

A. M. Aderounmu· 2 shared B. L. Bass· 2 shared B. Kolaczkowski· 1 shared C. D. Consalvo· 1 shared D. M. Eckert· 1 shared H. M. Donelick· 1 shared P. S. Shen· 1 shared

Activity by Year

2022-2023 · peak 1/yr

Co-Author Collaboration Network

7 top collaborators · 17 mutual co-author links

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2 shared papersBiochemistry

A. M. Aderounmu

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2 papers

Recent·Most cited

C. elegans Dicer acts with the RIG-I-like helicase DRH-1 and RDE-4 to cleave dsRNA

C. D. Consalvo, A. M. Aderounmu, H. M. Donelick, P. J. Aruscavage, D. M. Eckert, P. S. Shen, B. L. Bass

The paper investigates how C. elegans Dicer collaborates with DRH-1 and RDE-4 to cleave dsRNA, revealing their roles in antiviral defense mechanisms.

bioRxiv · Sep 21, 2023 · PreprintBiochemistry

Ancestral protein reconstruction reveals evolutionary events governing variation in Dicer helicase function

A. M. Aderounmu, P. J. Aruscavage, B. Kolaczkowski, B. L. Bass

This study uses ancestral protein reconstruction to show that vertebrate Dicer lost ATP hydrolysis function due to reduced dsRNA affinity, not just active site mutations.

bioRxiv · Dec 30, 2022Biochemistry