Author

P. S. Shen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:protein folding & dynamics· 4 Approach:biophysical modeling· 1 Organism:C. elegans· 1 Research Focus:cancer & tumor microenvironment· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1

Frequent Co-Authors

C. P. Hill· 2 shared S. Wang· 2 shared A. Frost· 1 shared A. J. Lazar· 1 shared A. M. Aderounmu· 1 shared A. Pozner· 1 shared B. A. Osuna· 1 shared B. Jensen· 1 shared

Activity by Year

2018-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

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2 shared papersBiochemistry

C. P. Hill

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Author profile →

5 papers

Recent·Most cited

ASPSCR1-TFE3 reprograms transcription by organizing enhancer loops around hexameric VCP/p97

A. Pozner, S. P. Verma, L. Li, S. Wang, J. J. Barrott, M. L. Nelson, J. S. E. Yu, G. L. Negri, S. Colborne, C. S. Hughes, J.-F. Zhu, S. L. Lambert, L. S. Carroll, K. Smith-Fry, M. G. Stewart, , K. B. Jones

This study identifies VCP/p97 as an obligate co-factor of ASPSCR1-TFE3, showing it organizes enhancer loops to drive oncogenic transcription in ASPS and RCC.

bioRxiv · Sep 29, 2023Cancer Biology

C. elegans Dicer acts with the RIG-I-like helicase DRH-1 and RDE-4 to cleave dsRNA

C. D. Consalvo, A. M. Aderounmu, H. M. Donelick, P. J. Aruscavage, D. M. Eckert, P. S. Shen, B. L. Bass

The paper investigates how C. elegans Dicer collaborates with DRH-1 and RDE-4 to cleave dsRNA, revealing their roles in antiviral defense mechanisms.

bioRxiv · Sep 21, 2023 · PreprintBiochemistry

Visualization of the Cdc48 AAA+ ATPase protein unfolding pathway

I. Cooney, H. L. Schubert, K. Cedeno, H.-J. L. Lin, J. C. Price, C. P. Hill, P. S. Shen

This study visualizes the Cdc48 AAA+ ATPase unfolding pathway using structural snapshots, revealing a hand-over-hand mechanism and the sequential ATP hydrolysis and substrate interaction between D1 and D2 subunits.

bioRxiv · May 13, 2023Biochemistry

Visualizing the chaperone-mediated folding trajectory of the G protein β5 β-propeller

S. Wang, M. I. Sass, Y. Kwon, W. G. Ludlam, T. M. Smith, E. J. Carter, N. E. Gladden, M. Riggi, J. H. Iwasa, B. M. Willardson, P. S. Shen

This study visualizes the chaperone-mediated folding trajectory of Gβ5 using cryo-EM, showing how CCT stabilizes intermediates to fold the β-propeller domain.

bioRxiv · May 4, 2023Biochemistry

Vms1p is a release factor for the Ribosome-associated Quality control Complex

O. Z. Rendon, E. K. Fredrickson, C. J. Howard, J. V. Vranken, S. Fogarty, N. D. Tolley, R. Kalia, B. A. Osuna, P. S. Shen, C. P. Hill, A. Frost, J. Rutter

This study identifies Vms1p as the tRNA hydrolase that releases nascent polypeptides in the RQC pathway for degradation.

bioRxiv · Apr 14, 2018Biochemistry