Cardiomyocyte BRAF and type 1 RAF inhibitors promote cardiomyocyte and cardiac hypertrophy in mice in vivo
A. Clerk, D. N. Meijles, M. A. Hardyman, S. J. Fuller, S. P. Chothani, J. J. Cull, S. T. Cooper, H. O. Alharbi, K. Vanezis, L. E. Felkin, T. Markou, S. J. Leonard, S. W. Shaw, O. J. Rackham, S. A. Cook, , P. H. Sugden
This study shows that BRAF activation induces cardiac hypertrophy in mice, and Type 1 RAF inhibitors paradoxically promote hypertrophy by increasing ERK1/2 phosphorylation.
bioRxiv · Aug 14, 2021Biochemistry