S. A. Cook

Interleukin-11 causes alveolar type 2 cell dysfunction and prevents alveolar regeneration

This study shows IL11 impairs AT2 cell differentiation into AT1 cells and blocks lung regeneration in mice and humans.

Cardiomyocyte BRAF and type 1 RAF inhibitors promote cardiomyocyte and cardiac hypertrophy in mice in vivo

This study shows that BRAF activation induces cardiac hypertrophy in mice, and Type 1 RAF inhibitors paradoxically promote hypertrophy by increasing ERK1/2 phosphorylation.

Overturning the paradigm that IL6 signaling drives liver regrowth while shining light on a new therapeutic target for regenerative medicine

The paper challenges the role of IL6 in liver regeneration, showing HyperIL6 protects against liver damage and promotes regeneration independently of STAT3, highlighting IL11 as a new therapeutic target.

Redefining Interleukin 11 as a regeneration-limiting hepatotoxin

This study reveals IL11 as a hepatotoxin that limits liver regeneration after APAP overdose, showing its inhibition of endogenous IL11 activity protects mice.

Fibroblast-specific IL11 signaling is required for lung fibrosis and inflammation

This study shows that fibroblast-specific IL11 signaling is critical for lung fibrosis and that inflammation can result from stromal activation rather than being a primary driver.

Genetic immunodeficiency and autoimmune disease reveal distinct roles of Hem1 in the WAVE2 and mTORC2 complexes

Hem1 loss-of-function mutations cause congenital immunodysregulation by disrupting WAVE2 and mTORC2 complexes, leading to immunodeficiency and immune hyperresponsiveness.