Author

C. F. McTiernan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:gene regulatory network inference· 1 Assay:metabolomics· 1

Frequent Co-Authors

A. Clerk· 1 shared B. A. Kaufman· 1 shared D. Guimaraes· 1 shared D. N. Meijles· 1 shared D. Thapa· 1 shared H. O. Alharbi· 1 shared I. Scott· 1 shared J. C. Sembrat· 1 shared

Activity by Year

2021-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperBiochemistry

A. Clerk

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Author profile →

2 papers

Recent·Most cited

Reduced acetylation of TFAM promotes bioenergetic dysfunction in the failing heart

M. Zhang, N. Feng, D. Thapa, M. W. Stoner, J. R. Manning, C. F. McTiernan, X. Yang, Z. Peng, M. J. Jurczak, D. Guimaraes, S. Shiva, B. A. Kaufman, M. N. Sack, I. Scott

This study shows that reduced GCN5L1 expression in the failing heart leads to mitochondrial dysfunction and decreased bioenergetic output.

bioRxiv · Oct 31, 2022Physiology

Cardiomyocyte BRAF and type 1 RAF inhibitors promote cardiomyocyte and cardiac hypertrophy in mice in vivo

A. Clerk, D. N. Meijles, M. A. Hardyman, S. J. Fuller, S. P. Chothani, J. J. Cull, S. T. Cooper, H. O. Alharbi, K. Vanezis, L. E. Felkin, T. Markou, S. J. Leonard, S. W. Shaw, O. J. Rackham, S. A. Cook, , P. H. Sugden

This study shows that BRAF activation induces cardiac hypertrophy in mice, and Type 1 RAF inhibitors paradoxically promote hypertrophy by increasing ERK1/2 phosphorylation.

bioRxiv · Aug 14, 2021Biochemistry