Author

J. C. Sembrat

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Immunology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Research Focus:metabolism & bioenergetics· 1 Organism:mouse· 1

Frequent Co-Authors

M. Rojas· 2 shared A. Clerk· 1 shared A. Das· 1 shared A. H. Wells· 1 shared A. Morris· 1 shared B. B. Chen· 1 shared B. J. McVerry· 1 shared B. Johnson· 1 shared

Activity by Year

2021-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersPhysiology

M. Rojas

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

GPER-dependent estrogen signaling increases cardiac GCN5L1 expression and MCAD activity

J. R. Manning, D. Thapa, M. Zhang, M. W. Stoner, J. C. Sembrat, M. Rojas, I. Scott

This study shows that estrogen signaling through GPER increases GCN5L1 expression and MCAD activity in cardiac cells, affecting mitochondrial enzyme acetylation and metabolic fuel utilization.

bioRxiv · Sep 20, 2021 · PreprintPhysiology

Cardiomyocyte BRAF and type 1 RAF inhibitors promote cardiomyocyte and cardiac hypertrophy in mice in vivo

A. Clerk, D. N. Meijles, M. A. Hardyman, S. J. Fuller, S. P. Chothani, J. J. Cull, S. T. Cooper, H. O. Alharbi, K. Vanezis, L. E. Felkin, T. Markou, S. J. Leonard, S. W. Shaw, O. J. Rackham, S. A. Cook, , P. H. Sugden

This study shows that BRAF activation induces cardiac hypertrophy in mice, and Type 1 RAF inhibitors paradoxically promote hypertrophy by increasing ERK1/2 phosphorylation.

bioRxiv · Aug 14, 2021Biochemistry

CD4+ T cell lymphopenia and dysfunction in severe COVID-19 disease is autocrine TNF-α/TNFRI-dependent

I. Popescu, M. E. Snyder, C. J. Iasella, S. J. Hannan, R. Koshy, R. Burke, A. Das, M. J. Brown, E. J. Lyons, S. C. Lieber, X. Chen, J. C. Sembrat, X. An, K. Linstrum, G. Kitsios, , J. F. McDyer

The paper shows that autocrine TNF-α/TNFRI signaling drives CD4+ T cell lymphopenia and dysfunction in severe COVID-19, and TNF-α blockade improves outcomes.

bioRxiv · Jun 2, 2021 · PreprintImmunology