Author

O. J. Rackham

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

A. Clerk· 2 shared D. N. Meijles· 2 shared H. O. Alharbi· 2 shared J. J. Cull· 2 shared P. H. Sugden· 2 shared S. T. Cooper· 2 shared C. F. McTiernan· 1 shared J. C. Sembrat· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersPhysiology

A. Clerk

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Author profile →

2 papers

Recent·Most cited

Striatin plays a major role in angiotensin II-induced cardiomyocyte and cardiac hypertrophy in mice in vivo.

J. J. Cull, S. T. Cooper, H. O. Alharbi, S. Chothani, O. J. Rackham, D. N. Meijles, P. R. Dash, R. Kerkela, N. Ruparelia, P. H. Sugden, A. Clerk

This paper shows that striatin (STRN) in cardiomyocytes is necessary for angiotensin II-induced cardiac hypertrophy and remodelling in mice, but not STRN3.

bioRxiv · Oct 21, 2023 · PreprintPhysiology

Cardiomyocyte BRAF and type 1 RAF inhibitors promote cardiomyocyte and cardiac hypertrophy in mice in vivo

A. Clerk, D. N. Meijles, M. A. Hardyman, S. J. Fuller, S. P. Chothani, J. J. Cull, S. T. Cooper, H. O. Alharbi, K. Vanezis, L. E. Felkin, T. Markou, S. J. Leonard, S. W. Shaw, O. J. Rackham, S. A. Cook, , P. H. Sugden

This study shows that BRAF activation induces cardiac hypertrophy in mice, and Type 1 RAF inhibitors paradoxically promote hypertrophy by increasing ERK1/2 phosphorylation.

bioRxiv · Aug 14, 2021Biochemistry