Author

S. P. Chothani

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

S. A. Cook· 2 shared A. A. Widjaja· 1 shared A. Clerk· 1 shared B. Ng· 1 shared B. S. Paleja· 1 shared C. F. McTiernan· 1 shared D. N. Meijles· 1 shared E. Adami· 1 shared

Activity by Year

2019-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersBiochemistry

S. A. Cook

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2 papers

Recent·Most cited

Cardiomyocyte BRAF and type 1 RAF inhibitors promote cardiomyocyte and cardiac hypertrophy in mice in vivo

A. Clerk, D. N. Meijles, M. A. Hardyman, S. J. Fuller, S. P. Chothani, J. J. Cull, S. T. Cooper, H. O. Alharbi, K. Vanezis, L. E. Felkin, T. Markou, S. J. Leonard, S. W. Shaw, O. J. Rackham, S. A. Cook, , P. H. Sugden

This study shows that BRAF activation induces cardiac hypertrophy in mice, and Type 1 RAF inhibitors paradoxically promote hypertrophy by increasing ERK1/2 phosphorylation.

bioRxiv · Aug 14, 2021Biochemistry

Fibroblast-specific IL11 signaling is required for lung fibrosis and inflammation

B. Ng, J. Dong, S. Viswanathan, A. A. Widjaja, B. S. Paleja, E. Adami, N. S. J. Ko, M. Wang, S. Lim, J. Tan, S. P. Chothani, S. Albani, S. Schafer, S. A. Cook

This study shows that fibroblast-specific IL11 signaling is critical for lung fibrosis and that inflammation can result from stromal activation rather than being a primary driver.

bioRxiv · Oct 11, 2019Cell Biology