Author

P. J. O'Toole

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cell Biology· 3 Cancer Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:microscopy & imaging analysis· 3 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Assay:imaging· 2 Organism:yeast· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1 Research Focus:clustering· 1

Frequent Co-Authors

C. MacDonald· 2 shared G. Calder· 2 shared A. D. James· 1 shared A. Milburn· 1 shared A. Simon· 1 shared D. D. Bisinski· 1 shared D. Ghete· 1 shared J. L. Marrison· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersCell Biology

C. MacDonald

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

High resolution live cell imaging to define ultrastructural and dynamic features of the halotolerant yeast Debaryomyces hansenii

M. S. C. Xelhuantzi, D. Ghete, A. Milburn, S. Ioannou, P. Mudd, G. Calder, J. Ramos, P. J. O'Toole, P. G. Genever, C. MacDonald

This study uses high-resolution live cell imaging to characterize sub-cellular structures and dynamic processes in the halotolerant yeast Debaryomyces hansenii, providing a template for studying genetically recalcitrant organisms.

bioRxiv · Mar 1, 2024 · PreprintCell Biology

Exploring the impact of variability in cell segmentation and tracking approaches

L. Wiggins, P. J. O'Toole, W. J. Brackenbury, J. Wilson

The paper quantifies variability in manual and automated cell segmentation and tracking methods, showing their impact on phenotypic metrics and reproducibility.

bioRxiv · Nov 24, 2023Cell Biology

Endosomal cargo recycling mediated by Gpa1 and Phosphatidylinositol-3-Kinase is inhibited by glucose starvation

K. M. Laidlaw, K. M. Paine, D. D. Bisinski, G. Calder, K. Hogg, S. Ahmed, S. James, P. J. O'Toole, C. MacDonald

The paper shows glucose starvation inhibits endosomal cargo recycling by altering PI3K activity through Gpa1 and Gpa2 interactions.

bioRxiv · Apr 2, 2021Cell Biology

Metastatic breast cancer cells induce altered microglial morphology and electrical excitability in vivo

A. Simon, M. Yang, J. L. Marrison, A. D. James, P. J. O'Toole, P. M. Kaye, M. A. Whittington, S. Chawla, W. Brackenbury

This study shows metastatic breast cancer cells alter microglial morphology and electrical activity in the brain, contributing to seizures and cognitive issues.

bioRxiv · May 14, 2019Cancer Biology