Author

P. J. Tuohy

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:experimental assay· 1 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

H. L. Parrish· 2 shared K. Lichauco· 2 shared K. Van Doorslaer· 2 shared M. S. Kuhns· 2 shared M. S. Lee· 2 shared C. Kim· 1 shared C. Y. Kim· 1 shared P. P. Yost· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 26 mutual co-author links

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2 shared papersImmunology

H. L. Parrish

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2 papers

Recent·Most cited

The CD4 transmembrane GGXXG and juxtamembrane (C/F)CV+C motifs mediate pMHCII-specific signaling independently of CD4-Lck interactions

M. S. Lee, P. J. Tuohy, C. Y. Kim, P. P. Yost, K. Lichauco, H. L. Parrish, K. Van Doorslaer, M. S. Kuhns

This study shows that CD4's GGXXG and (C/F)CV+C motifs are critical for pMHCII-specific signal amplification without requiring CD4-LCK interactions.

bioRxiv · May 5, 2023Immunology

Enhancing and inhibitory motifs have coevolved to regulate CD4 activity

M. S. Lee, P. J. Tuohy, C. Kim, K. Lichauco, H. L. Parrish, K. Van Doorslaer, M. S. Kuhns

The paper shows that enhancing and inhibitory motifs in CD4 coevolved to regulate pMHCII responses by fine-tuning signal relay across the cell membrane.

bioRxiv · Apr 29, 2021Immunology