Author

H. L. Parrish

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Immunology· 3 Bioengineering· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Organism:human· 1 Approach:statistical model· 1

Frequent Co-Authors

M. S. Kuhns· 4 shared M. S. Lee· 3 shared C. Y. Kim· 2 shared K. Lichauco· 2 shared K. Van Doorslaer· 2 shared P. J. Tuohy· 2 shared A. Karimzadeh· 1 shared C. Kim· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersImmunology

M. S. Kuhns

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

The CD4 transmembrane GGXXG and juxtamembrane (C/F)CV+C motifs mediate pMHCII-specific signaling independently of CD4-Lck interactions

M. S. Lee, P. J. Tuohy, C. Y. Kim, P. P. Yost, K. Lichauco, H. L. Parrish, K. Van Doorslaer, M. S. Kuhns

This study shows that CD4's GGXXG and (C/F)CV+C motifs are critical for pMHCII-specific signal amplification without requiring CD4-LCK interactions.

bioRxiv · May 5, 2023Immunology

The TCR Cα domain regulates responses to self-pMHCII

C. Y. Kim, H. L. Parrish, M. S. Kuhns

This study investigates the role of the TCR Cα domain in regulating CD4+ T cell responses to self-pMHCII, finding that mutations in this domain increase tonic signaling and homeostatic survival without affecting proliferation or differentiation.

bioRxiv · May 24, 2022 · PreprintImmunology

Enhancing and inhibitory motifs have coevolved to regulate CD4 activity

M. S. Lee, P. J. Tuohy, C. Kim, K. Lichauco, H. L. Parrish, K. Van Doorslaer, M. S. Kuhns

The paper shows that enhancing and inhibitory motifs in CD4 coevolved to regulate pMHCII responses by fine-tuning signal relay across the cell membrane.

bioRxiv · Apr 29, 2021Immunology

A biomimetic five-module chimeric antigen receptor (5MCAR) designed to target and eliminate antigen-specific T cells

S. Kobayashi, M. A. Thelin, H. L. Parrish, N. R. Deshpande, M. S. Lee, A. Karimzadeh, M. A. Niewczas, T. Serwold, M. S. Kuhns

This paper designs a biomimetic 5MCAR to target and eliminate antigen-specific T cells, showing it can mitigate type I diabetes in NOD mice.

bioRxiv · Jan 24, 2020Bioengineering