K. Van Doorslaer

The CD4 transmembrane GGXXG and juxtamembrane (C/F)CV+C motifs mediate pMHCII-specific signaling independently of CD4-Lck interactions

This study shows that CD4's GGXXG and (C/F)CV+C motifs are critical for pMHCII-specific signal amplification without requiring CD4-LCK interactions.

Characterization of 3D organotypic epithelial tissues reveals tonsil-specific differences in tonic interferon signaling

The paper compares gene expression in 3D-cultured epithelial tissues from foreskin, cervix, and tonsil to identify tissue-specific molecular mechanisms and immune-related differences.

A novel lineage of polyomaviruses identified in bark scorpions

The paper identifies eight novel polyomaviruses in bark scorpions and shows evidence of host-virus co-evolution with arthropods and chordates.

Enhancing and inhibitory motifs have coevolved to regulate CD4 activity

The paper shows that enhancing and inhibitory motifs in CD4 coevolved to regulate pMHCII responses by fine-tuning signal relay across the cell membrane.

Co-evolutionary analysis suggests a role for TLR9 in papillomavirus restriction

This study identifies TLR9 as a pattern recognition receptor involved in detecting papillomaviruses and shows co-evolution between papillomaviruses and their hosts.

Sequences in the Human papillomavirus Type 18 (HPV18) Upstream Regulatory Region regulate Viral Genome Replication, Establishment and Persistence

The paper identifies that the chromatin architecture, rather than specific elements, in the HPV18 upstream regulatory region is crucial for efficient viral genome replication and persistence.

Vesicular Trafficking Permits Evasion of cGAS/STING Surveillance During Initial Human Papillomavirus Infection

This paper shows that HPV evades cGAS/STING surveillance through unique vesicular trafficking, preventing cytosolic DNA detection and IFN responses.

Characterization of consensus operator site for Streptococcus pneumoniae copper repressor, CopY

This study identifies a more comprehensive consensus operator sequence for the copper repressor CopY in Streptococcus pneumoniae through bioinformatics and experimental validation.

Insertional oncogenesis by HPV70 revealed by multiple genomic analyses in a clinically HPV-negative cervical cancer

The paper identifies HPV70 insertion into BCL11B in an HPV-negative cervical cancer through genomic analyses, suggesting HPV70's oncogenic potential and novel BCL11B variants.